反应详情

A solution of ethyl-4-[3-(1-piperidinylmethyl)phenoxy]butanoate (6.1 g) and potassium hydroxide (6.0 g) in ethanol (50 ml) and water (50 ml) was heated under reflux during 0.5 h. The cool solution was neutralised to pH 7 with 5N hydrochloric acid, and evaporated to dryness under reduced pressure. The residue was dissolved in ethanol (100 ml), filtered and the filtrate was evaporated to leave a residue which was crystallised from a mixture of methanol and ether to give the title compound as a white crystalline solid (4.91 g) m.p. 73.5°; tlc System B, Rf 0.3.

1. temperatureunder reflux during 0.5 h
2. customevaporated to dryness under reduced pressure
3. dissolutionThe residue was dissolved in ethanol (100 ml)
4. filtrationfiltered
5. customthe filtrate was evaporated
6. customto leave a residue which
7. customwas crystallised from a mixture of methanol and ether