Hydrochloric Acid → 76955-73-2

HRID 485380Notes

Reaction equation

HRID 485380 reaction equation
[NH2:1][C:2]1[N:6]([CH3:7])[N:5]=[C:4]([C:8]([OH:10])=[O:9])[N:3]=1.Cl.[CH3:12]O>>[NH2:1][C:2]1[N:6]([CH3:7])[N:5]=[C:4]([C:8]([O:10][CH3:12])=[O:9])[N:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 20270329HCID 20270329, compound

Product 1

HCID 1675433476955-73-2

Procedure

A stirred suspension of 5-amino-1-methyl-1H-1,2,4-triazole-3-carboxylic acid (9.10 g) in methanol (100 ml) was saturated with dry hydrogen chloride, and heated under reflux for 4.5 h. The cooled solution was partially evaporated, diluted with water (100 ml) and the pH was adjusted to pH 7 with potassium carbonate. The solution was filtered, and the filtrate partially evaporated to give the title compound as a white solid (4.60 g) m.p. 190-1; tlc System B, Rf 0.6.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 4.5 h
  3. customThe cooled solution was partially evaporated
  4. additiondiluted with water (100 ml)
  5. filtrationThe solution was filtered
  6. customthe filtrate partially evaporated

Sources & evidence

ORD record
ord-0fccd8d6ff5b4f9398cda1e1c1005386
Source dataset
uspto-grants-1985_08
Patent number
US04536508

Reaction notes

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