反应详情

A mixture of ethyl 5-[4-[3-(1-piperidinylmethyl)phenoxy]butyl]amino-1H-1,2,4-triazole-3-carboxylate (0.3 g) and lithium aluminium hydride (0.1 g) in tetrahydrofuran (50 ml) was stirred at room temperature for 0.5 h, then quenched with water. The solid was filtered off and washed with methanol. The filtrate and washings were evaporated to leave a residue which was extracted with hot ethyl acetate. Evaporation of the extract gave an oil that solidified. It was crystallised from ethyl acetate to give the title compound as an off-white solid (0.094 g) m.p. 127°-8° dec. tlc System B, Rf 0.7.

1. customquenched with water
2. filtrationThe solid was filtered off
3. washwashed with methanol
4. customThe filtrate and washings were evaporated
5. customto leave a residue which
6. extractionwas extracted with hot ethyl acetate
7. customEvaporation of the extract
8. customgave an oil that solidified
9. customIt was crystallised from ethyl acetate