3-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine → HCID 178486228, compound

HRID 485390Notes

Reaction equation

HRID 485390 reaction equation
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=2)[O:11][CH2:12][CH2:13][CH2:14][NH2:15])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:19][N:20]([C:29](SC)=[N:30][C:31](=[O:39])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[N:21]=[CH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C1CCCCC1>[CH3:19][N:20]([C:29]([NH:15][CH2:14][CH2:13][CH2:12][O:11][C:10]1[CH:16]=[CH:17][CH:18]=[C:8]([CH2:7][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:9]=1)=[N:30][C:31](=[O:39])[CH2:32][C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)[N:21]=[CH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 102205613-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amineHCID 53734358HCID 53734358, compound

Product 1

HCID 178486228HCID 178486228, compoundYield 80.8%

Reagents, catalysts & solvents 1

HCID 8078CyclohexaneSolvent

Procedure

A mixture of 3-[3-(1-piperidinylmethyl)phenoxy]propanamine (0.38 g) and methyl 1-methyl-N-phenylacetyl-2-(phenylmethylene)hydrazinecarboximidothioate (0.5 g) was heated at 50° under water pump vacuum during 4 h. The residue was dissolved in cyclohexane (20 ml) and light petroleum (b.p. 60°-80°) was added. The precipitate was removed by filtration and the filtrate was evaporated to give the title compound (0.65 g) as a colourless oil. tlc. System A Rf 0.7.

Workup

  1. temperaturewas heated at 50° under water pump vacuum during 4 h
  2. customThe precipitate was removed by filtration
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-7f80984e786f43079ab66074415a8947
Source dataset
uspto-grants-1985_08
Patent number
US04536508

Reaction notes

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