3-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine → HCID 178486228, compound

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Reaction Steps

A mixture of 3-[3-(1-piperidinylmethyl)phenoxy]propanamine (0.38 g) and methyl 1-methyl-N-phenylacetyl-2-(phenylmethylene)hydrazinecarboximidothioate (0.5 g) was heated at 50° under water pump vacuum during 4 h. The residue was dissolved in cyclohexane (20 ml) and light petroleum (b.p. 60°-80°) was added. The precipitate was removed by filtration and the filtrate was evaporated to give the title compound (0.65 g) as a colourless oil. tlc. System A Rf 0.7.

Provenance & Evidence