Acetic Acid → HCID 53864591, compound

HRID 485392Notes

Reaction equation

HRID 485392 reaction equation
[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:14]=2)=[N:5][C:4]([CH2:26][OH:27])=[N:3]1.[C:28](O)(=[O:30])[CH3:29]>>[C:28]([O:27][CH2:26][C:4]1[N:5]=[C:6]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:14]=2)[N:2]([CH3:1])[N:3]=1)(=[O:30])[CH3:29]

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 20199146HCID 20199146, compound

Product 1

HCID 53864591HCID 53864591, compound

Procedure

A solution of 1-methyl-5-[[4-[3-(1-piperidinylmethyl)phenoxy]butyl]amino]-1H-1,2,4-triazole-3-methanol (100 mg) in glacial acetic acid (5 ml) was heated under reflux for 8 h. The mixture was evaporated and the residue was triturated with ether to give the title compound as a white solid (97 mg) m.p. 119°-20°. tlc. System B,Rf 0.8.

Workup

  1. temperatureunder reflux for 8 h
  2. customThe mixture was evaporated
  3. customthe residue was triturated with ether

Sources & evidence

ORD record
ord-0e0bd1a1cd1c448a908eacd050e09e85
Source dataset
uspto-grants-1985_08
Patent number
US04536508

Reaction notes

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