1-(4-Hydroxyphenyl)-2-phenylbutan-1-one → 1-(4-Methoxyphenyl)-2-phenylbutan-1-one
Reaction equation
CN(C)C[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH:14]([CH3:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:13])=[CH:8][CH:7]=1.[CH2:23](C(C1C=CC=CC=1)C(=O)C1C=CC(O)=CC=1)C>>[CH2:21]([CH:14]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:12](=[O:13])[C:9]1[CH:10]=[CH:11][C:6]([O:5][CH3:4])=[CH:7][CH:8]=1)[CH3:23]Participants
3
Procedure
4-(β-Dimethylaminoethoxy)-α-ethyldesoxybenzoin (b.p. 162° C./0.075 mm.) may be obtained from α-ethyl-4-hydroxydesoxybenzoin by an analogous procedure to that described below for the preparation of 4-(β-dimethylaminoethoxy)-α-methyldesoxybenzoin, and α-ethyl-4-hydroxydesoxybenzoin itself (m.p. 122°-124° C.) may be obtained from α-ethyl-4-methoxydesoxybenzoin by an analogous procedure to that described below for the preparation of 4-hydroxy-α-methyldesoxybenzoin.
Sources & evidence
- ORD record
- ord-74f512026c40454b863dc61d6094d425
- Source dataset
- uspto-grants-1985_08
- Patent number
- US04536516
Reaction notes
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