反应详情

A mixture of 12.3 g. of 1-propyl bromide, 13.6 g. of 4-hydroxyacetophenone, 27.6 g. of potassium carbonate and 200 ml. of acetone was refluxed overnight. The mixture was then cooled, filtered, the filtrate concentrated and distilled in a Kugelrohr. The distillate was dissolved in ethyl acetate, treated with charcoal, filtered through diatomaceous earth, concentrated and dried, giving the desired intermediate as an oil.

1. additionA mixture of 12.3 g
2. temperatureThe mixture was then cooled
3. filtrationfiltered
4. concentrationthe filtrate concentrated
5. distillationdistilled in a Kugelrohr
6. dissolutionThe distillate was dissolved in ethyl acetate
7. additiontreated with charcoal
8. filtrationfiltered through diatomaceous earth
9. concentrationconcentrated
10. customdried