Acetic Acid → HCID 20270263, compound

HRID 485452Notes

Reaction equation

HRID 485452 reaction equation
C([NH:4][C:5]1[CH:6]=[CH:7][C:8]2[S:14][C:13]3[CH:15]=[C:16]([C:19]([OH:21])=[O:20])[CH:17]=[CH:18][C:12]=3[CH2:11][CH2:10][C:9]=2[CH:22]=1)(=O)C.C(O)(=O)C.S(=O)(=O)(O)O>O>[NH2:4][C:5]1[CH:6]=[CH:7][C:8]2[S:14][C:13]3[CH:15]=[C:16]([C:19]([OH:21])=[O:20])[CH:17]=[CH:18][C:12]=3[CH2:11][CH2:10][C:9]=2[CH:22]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 20270221HCID 20270221, compound

Product 1

HCID 20270263HCID 20270263, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Reflux 200 mg. of 8-acetamido-10,11-dihydrodibenzo[b,f]thiepin-3-carboxylic acid for 16 hours in a mixture of 5 cc. of acetic acid and 5 cc. of 50% aqueous sulfuric acid. Dilute with water and separate the solids by filtration. Wash with water and dry to obtain the title product.

Workup

  1. temperatureReflux 200 mg
  2. customseparate the solids
  3. filtrationby filtration
  4. washWash with water
  5. customdry

Sources & evidence

ORD record
ord-d4a694bf191440d0b5560e8f48a7673f
Source dataset
uspto-grants-1985_08
Patent number
US04536507

Reaction notes

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