Hydrochloric Acid → HCID 13151871, compound

HRID 485453Notes

Reaction equation

HRID 485453 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7]2S[C:12]3[CH:14]=[C:15]([C:18]([OH:20])=[O:19])[CH:16]=[CH:17][C:11]=3[CH2:10][CH2:9][C:8]=2[CH:21]=1)(=[O:3])C.Cl[O-:23].[Na+].[OH-].[Na+].[S:27](S([O-])=O)([O-:30])(=O)=[O:28].[Na+].[Na+].Cl>>[CH:17]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:21]=[C:4]([C:1]([OH:3])=[O:23])[CH:5]=[CH:6][C:7]=3[S:27](=[O:30])(=[O:28])[C:12]=2[CH:14]=[C:15]([C:18]([OH:20])=[O:19])[CH:16]=1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 656671Sodium PyrosulfiteHCID 13151869HCID 13151869, compoundHCID 23665760Sodium Hypochlorite

Product 1

HCID 13151871HCID 13151871, compound

Conditions

Temperature
85 °C

Procedure

Add 1.85 g. of 8-acetyl-10,11-dihydrodibenzo[b,f]thiepin-3-carboxylic acid to a stirred mixture of 370 ml. of 50% aqueous sodium hypochlorite and 13 ml. of 20% aqueous sodium hydroxide at 60° C. Raise the temperature to 85° C. and stir for 30 minutes. Pour the mixture over ice and add sodium metabisulfite Acidify with 6N hydrochloric acid. Separate the solids by filtration wash with water and dry to obtain the title product. (m.p. 350°-352° C.)

Workup

  1. additionAdd 1.85 g
  2. customat 60° C
  3. additionPour the mixture over ice
  4. customSeparate the solids
  5. filtrationby filtration
  6. washwash with water
  7. customdry

Sources & evidence

ORD record
ord-3dbff3190ec442b09a592a0f50786678
Source dataset
uspto-grants-1985_08
Patent number
US04536507

Reaction notes

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