Dimethyl malonate → HCID 178437790, compound

HRID 485498Notes

Reaction equation

HRID 485498 reaction equation
C(O)(=O)C.[C:5]([NH2:9])(=[NH:8])[CH2:6][CH3:7].[C:10](OC)(=[O:16])[CH2:11][C:12](OC)=[O:13]>C[O-].[Na+]>[OH:13][C:12]1[CH:11]=[C:10]([OH:16])[N:9]=[C:5]([CH2:6][CH3:7])[N:8]=1

Participants

4

Reactant 2

HCID 7943Dimethyl malonateHCID 12301254HCID 12301254, compound

Product 1

HCID 178437790HCID 178437790, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 10942334Sodium MethoxideSolvent

Procedure

Using the procedure of Example 1, Part B1, 18.5 g (0.14 mole) of propionamidine acetate and 90 ml of 25% sodium methoxide were reacted with dimethyl malonate (0.14 mole) to provide 16.5 g (89.5%) of 4,6-dihydroxy-2ethylpyrimidine according to Step (1).

Sources & evidence

ORD record
ord-34d580d67bef4d9c9b06435ad359997f
Source dataset
uspto-grants-1985_08
Patent number
US04536579

Reaction notes

Loading…