HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 2-Ethyl-6-hydrazinyl-4-(4-methyl-1-piperazinyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 4-Chloro-2-ethyl-6-hydrazinylpyrimidine | HCID 13393613 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Ethyl-6-hydrazinyl-4-(4-methyl-1-piperazinyl)pyrimidine | HCID 13393614 | 70.2% |
Reaction Steps
A mixture of 8.3 g (0.05 mole) of 4-chloro-2-ethyl-6-hydrazinylpyrimidine and 11 g (0.10 mole) of 1-methylpiperazine in 250 ml of water was heated at reflux for 16 hours and was then cooled and extracted with chloroform. The extracts were dried over magnesium sulfate and were then evaporated to provide 8.3 g (70%) of 2-ethyl-6-hydrazinyl-4-(4-methyl-1-piperazinyl)pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04536579 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-e311fa27bfdb4e8db42225113672fd36 |
| Source note | uspto-grants-1985_08 |