1-Methylpiperazine → 2-Ethyl-6-hydrazinyl-4-(4-methyl-1-piperazinyl)pyrimidine

HRID 485500Notes

Reaction equation

HRID 485500 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][NH2:9])[N:5]=[C:4]([CH2:10][CH3:11])[N:3]=1.[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>O>[CH2:10]([C:4]1[N:3]=[C:2]([N:16]2[CH2:17][CH2:18][N:13]([CH3:12])[CH2:14][CH2:15]2)[CH:7]=[C:6]([NH:8][NH2:9])[N:5]=1)[CH3:11]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 133936134-Chloro-2-ethyl-6-hydrazinylpyrimidine

Product 1

HCID 133936142-Ethyl-6-hydrazinyl-4-(4-methyl-1-piperazinyl)pyrimidineYield 70.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 8.3 g (0.05 mole) of 4-chloro-2-ethyl-6-hydrazinylpyrimidine and 11 g (0.10 mole) of 1-methylpiperazine in 250 ml of water was heated at reflux for 16 hours and was then cooled and extracted with chloroform. The extracts were dried over magnesium sulfate and were then evaporated to provide 8.3 g (70%) of 2-ethyl-6-hydrazinyl-4-(4-methyl-1-piperazinyl)pyrimidine.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. temperaturewas then cooled
  4. extractionextracted with chloroform
  5. dry with materialThe extracts were dried over magnesium sulfate
  6. customwere then evaporated

Sources & evidence

ORD record
ord-e311fa27bfdb4e8db42225113672fd36
Source dataset
uspto-grants-1985_08
Patent number
US04536579

Reaction notes

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