反应详情

温度

35 °C

5-(4-Methoxybenzyl)-2-thiouracil (105 g) was refluxed in glacial acetic acid (800 ml) and 48% aqueous hydrobromic acid (400 ml) for 3 hrs. The solution was cooled to ca. 35° C., methyl iodide (53 ml) was added and the solution was refluxed for a further 2 hours. The mixture was evaporated to dryness in vacuo and water (500 ml) added to the residue. Sodium hydroxide was added to raise the pH to ca. 5. The solid which formed was filtered off and recrystallised from ethanol giving 4-hydroxybenzyl-2-methylthio-4-pyrimidone (43.1 g) m.p. 243°-4° C.

1. temperaturethe solution was refluxed for a further 2 hours
2. customThe mixture was evaporated to dryness in vacuo and water (500 ml)
3. additionadded to the residue
4. additionSodium hydroxide was added
5. temperatureto raise the pH to ca. 5
6. customThe solid which formed
7. filtrationwas filtered off
8. customrecrystallised from ethanol