反应详情

5-Bromo-2-(4-aminobutyl)-3-methylpyridine, (0.58 g) and 5-(3-methoxybenzyl)-2-methylthio-4-pyrimidone (0.51 g) were refluxed in pyridine (3 ml) for 3 hours. The pyridine was removed in vacuo. The residue was recrystallised from ethanol/water giving 2-[4-(5-bromo-3-methylpyrid-2-yl)butylamino]-5-(3-methoxybenzyl)-4-pyrimidone (0.60 g). Softens 65° C., melts 73° C.

1. customThe pyridine was removed in vacuo
2. customThe residue was recrystallised from ethanol/water