HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone → 2-[4-(5-Bromo-3-methylpyrid-2-yl)butylamino]-5-(3-methoxybenzyl)-4-pyrimidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(3-Methoxybenzyl)-2-methylthio-4-pyrimidone | HCID 12951526 | — |
| Reactant | 4-(5-Bromo-3-methyl-2-pyridinyl)butylamine | HCID 13094272 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-[4-(5-Bromo-3-methylpyrid-2-yl)butylamino]-5-(3-methoxybenzyl)-4-pyrimidone | HCID 20269070 | 67.5% |
Reaction Steps
5-Bromo-2-(4-aminobutyl)-3-methylpyridine, (0.58 g) and 5-(3-methoxybenzyl)-2-methylthio-4-pyrimidone (0.51 g) were refluxed in pyridine (3 ml) for 3 hours. The pyridine was removed in vacuo. The residue was recrystallised from ethanol/water giving 2-[4-(5-bromo-3-methylpyrid-2-yl)butylamino]-5-(3-methoxybenzyl)-4-pyrimidone (0.60 g). Softens 65° C., melts 73° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04537891 |
| Source dataset | uspto-grants-1985_08 |
| ORD ID | ord-2dbcfc037ec942309b5e2f15fb2948ff |
| Source note | uspto-grants-1985_08 |