HCID 54125717, compound → HCID 13338743, compound

Participants

Reaction Steps

A solution of benzyl 5-(2-aminophenyl)-2-phthalimido-4-penteneoate (10.7 g) in ethanol (500 ml) is hydrogenated at atmospheric pressure with 10% palladium on charcoal (2 g) until uptake ceases. The catalyst is filtered off and the filtrate evaporated under reduced pressure. The residue is triturated with ethyl acetate to give 5-(2-aminophenyl)-2-phthalimidopentanoic acid, mp 258°-260°, used without further purification in the next synthetic step.

Provenance & Evidence