(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile → HCID 131714315, compound

HRID 485718Notes

Reaction equation

HRID 485718 reaction equation
[CH3:1][C:2]1([CH3:12])[C@H:4]([CH:5]=[C:6]=[CH:7][Cl:8])[C@H:3]1[C:9]([OH:11])=[O:10].[C:13]([C@@H:15](O)[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=1)#[N:14]>C(Cl)(Cl)Cl>[CH3:1][C:2]1([CH3:12])[C@H:4]([CH:5]=[C:6]=[CH:7][Cl:8])[C@H:3]1[C:9]([O:11][C@H:15]([C:13]#[N:14])[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:17]=1)=[O:10]

Participants

4

Reactant 2

HCID 9837437(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrileHCID 131714316HCID 131714316, compound

Product 1

HCID 131714315HCID 131714315, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Using the procedure of Example 1, 0.6 g of the acid of Step C of Example 27 and 0.73 g of (S)α-cyano-3-phenoxy-benzyl alcohol were reacted to obtain 1.0 g of (S)α-cyano-3-phenoxybenzyl (1R,trans) 2,2-dimethyl-3-(3-chloro-1,2-propadienyl)cyclopropane-carboxylate with a specific rotation of [α]D20 =+26°±2° (c=0.75% in CHCl3).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-83268f83f19c4df899a708a398db909b
Source dataset
uspto-grants-1985_08
Patent number
US04537897

Reaction notes

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