反应详情

To 4.2 g. of 1(o-benzylaminobenzoyl)-1H-indazol-3-ol dissolved in 1 liter of absolute EtOH was added 1.4 g of 10% Pd/C and the mixture was hydrogenated in a Paar apparatus for 16 hrs. The catalyst was then filtered off, washed well with EtOH, and the filtrate evaporated to afford 2.3 g. of a yellow-green solid. Recrystallization from aqueous. EtOH afforded the desired amine as a light yellow solid in 66.7% yield; m.p. 181°-183° C.

1. filtrationThe catalyst was then filtered off
2. washwashed well with EtOH
3. customthe filtrate evaporated
4. customto afford 2.3 g
5. customRecrystallization from aqueous