2-Fluoro-1-phenylethan-1-one → 2-Bromo-2-fluoro-1-phenylethan-1-one

HRID 485884Notes

Reaction equation

HRID 485884 reaction equation
[F:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[Br:11]Br>CCOCC.C(Cl)(Cl)Cl>[Br:11][CH:2]([F:1])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4]

Participants

5

Reactant 2

HCID 99472-Fluoro-1-phenylethan-1-oneHCID 24408Bromine

Product 1

HCID 125451272-Bromo-2-fluoro-1-phenylethan-1-one

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

To a solution of 2.76 g of 2-fluoroacetophenone in 50 ml of ether is added dropwise over 30 minutes a solution of 3.2 g of bromine in 10 ml of chloroform. Evaporation of the reaction mixture under reduced pressure affords α-bromo-2-fluoroacetophenone.

Workup

  1. customEvaporation of the reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-91fefa60659740b49cc3e268c3565548
Source dataset
uspto-grants-1985_08
Patent number
US04537976

Reaction notes

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