反应详情

温度

40 °C

Hydrogen gas was blown into a mixture of 21 g of 4,6-dichloro-5-methoxy-2-(4-benzyloxyphenyl)pyrimidine, 18.1 g of triethylamine, 3.15 g of 10% palladium-on-carbon, 210 ml of ethanol, and 11 ml of water, followed by stirring at 40° C. for 6 hours. The catalyst was removed by filtration, and the filtrate was poured into 300 ml of water and extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and distilled to remove ethyl acetate to afford 8.93 g (percent yield: 90.9%) of 5-methoxy-2-(4-hydroxyphenyl)pyrimidine.

1. customThe catalyst was removed by filtration
2. additionthe filtrate was poured into 300 ml of water
3. extractionextracted with ethyl acetate
4. dry with materialThe extract was dried over anhydrous sodium sulfate
5. distillationdistilled
6. customto remove ethyl acetate