反应详情

A mixture of 8.42 g of 5-methoxy-2-(4-benzyloxyphenyl)pyrimidine, 6.9 g of sodium hydroxide, and 84 ml of diethylene glycol was heated at 190° to 200° C. for 2 hours. After cooling, the reaction mixture was poured into 300 ml of water, neutralized with a 1% hydrochloric acid aqueous solution, and extracted with ethyl acetate. Distillation of the extract to remove ethyl acetate gave 7.3 g (26.2 mmol; percent yield: 91.8%) of 5-hydroxy-2-(4-benzyloxyphenyl)pyrimidine.

1. temperaturewas heated at 190° to 200° C. for 2 hours
2. temperatureAfter cooling
3. extractionextracted with ethyl acetate
4. distillationDistillation of the
5. extractionextract
6. customto remove ethyl acetate