反应详情

In a 2 l four-necked flask were charged 25.3 g (51.2 mmol) of the compound obtained in step 1, 506 ml of THF, and 506 ml of methanol. After purging the flask with nitrogen, 5 g of 10% palladium-on-carbon was added thereto to conduct hydrogenation at 30° to 35° C. under atmospheric pressure for 2 hours. After completion of the reaction, the catalyst was removed by filtration in a nitrogen stream, and the solvent was recovered to afford 20.18 g of the titled compound.

1. customAfter purging the flask with nitrogen, 5 g of 10% palladium-on-carbon
2. additionwas added
3. customat 30° to 35° C.
4. customfor 2 hours
5. customAfter completion of the reaction
6. customthe catalyst was removed by filtration in a nitrogen stream
7. customthe solvent was recovered