反应详情

温度

0 °C

To a solution of 0.60 g of 2-butyl-1,4-dihydro-4-oxo-6-quinazoline-carboxaldehyde in 30 ml of dry tetrahydrofuran, cooled to 0° C. is added dropwise, 2.61 ml of a 3.0M solution of methylmagnesium bromide in diethyl ether. The reaction is stirred at 0° C. for 30 minutes and then quenched with 10 ml of aqueous ammonium chloride. After diluting with 10 ml of water, the reaction mixture is extracted with 9:1 chloroform-methanol. The combined extracts are dried with magnesium sulfate, filtered and concentrated to yield 0.64 g of the desired product. CI MASS SPEC 247(MH+).

1. additionis added dropwise
2. customquenched with 10 ml of aqueous ammonium chloride
3. additionAfter diluting with 10 ml of water
4. extractionthe reaction mixture is extracted with 9:1 chloroform-methanol
5. dry with materialThe combined extracts are dried with magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated