関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Oxalic Acid | HCID 971 | — |
| 反応物 | Phenethyl Isothiocyanate | HCID 16741 | — |
| 反応物 | 4-(1H-imidazol-4-yl)piperidine | HCID 178420873 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | HCID 178526031 | HCID 178526031 | — |
反応手順
A solution of 1.63 g (0.01 mol) of phenethyl isothiocyanate in 60 ml of toluene and 1.51 g (0.01 mol) of 4-(4-imidazolyl)piperidine is heated to reflux for 1h 30 min. After cooling, the solution is evaporated under reduced pressure and the residual oil obtained is dissolved in 60 ml of isopropanol in the presence of 1.2 equivalents of oxalic acid. After 30 minutes of heating at 80° C., the white precipitate formed is drained, washed with ether and recrystallised in acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05290790 |
|---|
| 出典データセット | uspto-grants-1994_03 |
|---|
| ORD ID | ord-474f4c34d56c412e9d2b44ede976dcb9 |
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| 出典メモ | uspto-grants-1994_03 |
|---|
