反应详情

温度

80 °C

A solution of 1.63 g (0.01 mol) of phenethyl isothiocyanate in 60 ml of toluene and 1.51 g (0.01 mol) of 4-(4-imidazolyl)piperidine is heated to reflux for 1h 30 min. After cooling, the solution is evaporated under reduced pressure and the residual oil obtained is dissolved in 60 ml of isopropanol in the presence of 1.2 equivalents of oxalic acid. After 30 minutes of heating at 80° C., the white precipitate formed is drained, washed with ether and recrystallised in acetonitrile.

1. temperatureAfter cooling
2. customthe solution is evaporated under reduced pressure
3. customthe residual oil obtained
4. customthe white precipitate formed
5. washwashed with ether
6. customrecrystallised in acetonitrile