Butyl isocyanate → HCID 19097340, compound

HRID 486067Notes

Reaction equation

HRID 486067 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH2:17][CH2:18][NH2:19])=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)=[CH:4][CH:3]=1.[CH2:22]([N:26]=[C:27]=[O:28])[CH2:23][CH2:24][CH3:25]>N1C=CC=CC=1>[CH2:22]([NH:26][C:27]([NH:19][CH2:18][CH2:17][O:16][C:12]1[CH:11]=[C:10]2[C:15](=[CH:14][CH:13]=1)[N:7]([CH2:6][C:5]1[CH:20]=[CH:21][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH:8]=[CH:9]2)=[O:28])[CH2:23][CH2:24][CH3:25]

Participants

4

Reactant 2

HCID 8110Butyl isocyanateHCID 54389124HCID 54389124, compound

Product 1

HCID 19097340HCID 19097340, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a mixture of 1-(4-chlorobenzyl)-5-(aminoethoxy)-indole (1.0 g) in pyridine (I ml), butyl isocyanate (0.5 ml) was added at ambient temperature. After stirring for 15 minutes, excess pyridine was evaporated in vacuo and the residue recrystallized from ethanol to yield the title product, m.p. 163°-164° C.

Workup

  1. additionwas added at ambient temperature
  2. customexcess pyridine was evaporated in vacuo
  3. customthe residue recrystallized from ethanol

Sources & evidence

ORD record
ord-fb8cbba2fbac44c19ce842ae5c561366
Source dataset
uspto-grants-1994_03
Patent number
US05290788

Reaction notes

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