Cyclopentanone → HCID 19097476, compound

Participants

Reaction Steps

A mixture of 1,2,3,4-tetramethyl-3-piperidineethanamine (2.0 g, 10.7 mmol), ethanol (50 mL), cyclopentanone (950 μL, 10.7 mmol) and 10% palladium on carbon (1.0 g) was placed on a Parr hydrogenator under 50 psi of hydrogen pressure for four hours. The reaction mixture was filtered to remove the catalyst and the solvent was removed in vacuo to afford 2.5 g (93%) of N-cyclopentyl-1,2,3,4-tetramethyl-3-piperidineethanamine as a yellow oil. The product was dissolved in ether/ethanol and treated with ethereal HCl to afford the product as a dihydrochloride hemihydrate. The dihydrochloride hemihydrate was isolated as a white powder and had a melting point of 201°-202.5° C.

Provenance & Evidence