Ammonia → HCID 178440893, compound

HRID 486116Notes

Reaction equation

HRID 486116 reaction equation
N.[C:2]([C:6]1[CH:11]=[CH:10][C:9]([C@@H:12]2[CH2:17][CH2:16][C@H:15]([NH2:18])[CH2:14][CH2:13]2)=[CH:8][CH:7]=1)([CH3:5])([CH3:4])[CH3:3]>>[C:2]([C:6]1[CH:11]=[CH:10][C:9]([C@H:12]2[CH2:13][CH2:14][C@H:15]([NH2:18])[CH2:16][CH2:17]2)=[CH:8][CH:7]=1)([CH3:5])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178440892HCID 178440892, compound

Product 1

HCID 178440893HCID 178440893, compound

Procedure

The free base is obtained therefrom by adding aqueous ammonia solution, extracting the mixture with methyl tert-butyl ether, and drying and evaporating the organic phase to give a colorless oil (cis/trans mixture). Characteristic NMR data (CDCl3): cis-4-(4-tertbutylphenyl)cyclohexylamine: δ1-Heq =3.19; γ C-1=45.3 ppm.

Workup

  1. customThe free base is obtained
  2. extractionextracting the mixture with methyl tert-butyl ether
  3. customdrying
  4. customevaporating the organic phase
  5. customto give a colorless oil (cis/trans mixture)

Sources & evidence

ORD record
ord-0072a8af84594b48b562174cdfd62079
Source dataset
uspto-grants-1994_03
Patent number
US05290806

Reaction notes

Loading…