Hydrochloric Acid → FK1052 hydrochloride

HRID 486189Notes

Reaction equation

HRID 486189 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12.[ClH:23]>CO.C(O)C>[ClH:23].[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:22])[CH:12]([CH2:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 125368FK 1052

Product 1

HCID 9949384FK1052 hydrochloride

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 887MethanolSolvent

Procedure

The suspension of 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one (2.0 g) in methanol (60 ml) was treated with hydrogen chloride in ethanol and then diluted with hot aqueous ethanol (water:ethanol, 1:4) to give a clear solution. After filtration of the insoluble materials, the filtrate was evaporated under reduced pressure to about 40 ml and allowed to stand at room temperature overnight. Filtration, followed by washing with ethanol, gave 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one hydrochloride (2.10 g) as crystals.

Workup

  1. customto give a clear solution
  2. filtrationAfter filtration of the insoluble materials
  3. customthe filtrate was evaporated under reduced pressure to about 40 ml
  4. filtrationFiltration
  5. washby washing with ethanol

Sources & evidence

ORD record
ord-ce7ea70b3a9840f984da19c53a88fc39
Source dataset
uspto-grants-1994_03
Patent number
US05290785

Reaction notes

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