反应详情

Ethyl 1,6-dihydro-6-oxo-2-(2-propoxyphenyl)pyrimidine-5-carboxylate (1 g, U.S. Pat. No. 4,031,093) was treated with methylamine (33% in industrial methylated spirit, 50 ml) in a pressure vessel (379 kPa) at 120° C. for six hours and then allowed to cool. Solvent was removed under reduced pressure to afford a white solid which was triturated with ether, 0.88 g, m.p. 190°-191° C. This solid together with another sample prepared similarly (0.32 g) was recrystallised from ethanol to afford the title compound, 0.98 g, m.p. 192°-193° C.

1. temperatureto cool
2. customSolvent was removed under reduced pressure
3. customto afford a white solid which
4. customwas triturated with ether, 0.88 g, m.p. 190°-191° C
5. customThis solid together with another sample prepared similarly (0.32 g)
6. customwas recrystallised from ethanol