反应详情

7.61 g (21.3 mmol) of N-(3-isopropylphenyl)-N-(2-oxobutyl)-3-chlorophenylacetamide synthesized in Example 2 or 3 were dissolved in 35 ml of ethanol, and 0.1 ml of an ethanol solution containing 30% of sodium ethoxide was added at room temperature with stirring. The solution was successively stirred at the same temperature for 2 hours, and the resultant reaction mixture was poured into water, followed by extraction with ethyl acetate. The solvent was distilled off under reduced pressure, and the solution was then purified through silica gel column chromatography (an eluent: hexane/ethyl acetate=4/1) to obtain 5.9 g of the desired product in an oily state (yield: 77.5%).

1. additionwas added at room temperature
2. stirringThe solution was successively stirred at the same temperature for 2 hours
3. customthe resultant reaction mixture
4. extractionfollowed by extraction with ethyl acetate
5. distillationThe solvent was distilled off under reduced pressure
6. customthe solution was then purified through silica gel column chromatography (an eluent