HCID 178511233, compound → HCID 178511234, compound

HRID 486369Notes

Reaction equation

HRID 486369 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][C@H:17]3[CH2:22][CH2:21][C@H:20]([C:23]#[N:24])[CH2:19][CH2:18]3)=[CH:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]>C1(C)C=CC=CC=1.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C@H:17]3[CH2:22][CH2:21][C@H:20]([C:23]#[N:24])[CH2:19][CH2:18]3)=[CH:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 1

HCID 178511233HCID 178511233, compound

Product 1

HCID 178511234HCID 178511234, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 1140TolueneSolvent

Procedure

A solution of 4.9 g of trans-4-[2-[2-(3,4-difluorophenyl)-5-pyridyl]vinyl]cyclohexanecarbonitrile in 120 ml of toluene is hydrogenated with 0.5 g of 10 percent palladium/carbon at room temperature and normal pressure. Filtration and evaporation of the filtrate yields trans-4-[2-[2-(3,4-difluorophenyl)-5-pyridyl]ethyl]cyclohexanecarbonitrile.

Workup

  1. filtrationFiltration and evaporation of the filtrate

Sources & evidence

ORD record
ord-c097127435f1486cbe694bd975baa097
Source dataset
uspto-grants-1994_03
Patent number
US05292452

Reaction notes

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