反应详情

A mixture of Compound 12 (3.90 g, 13.3 mmole), ethyl acetoacetate (1.94 g, 14.9 mmole), and acetic acid (8.2 mL) was heated at reflux in a dry nitrogen atmosphere overnight. On cooling, the mixture solidified. The solid was collected, washed with cold ethanol and recrystallized from ethanol to yield Compound 20 (4.03 g, 74% yield), m.p. 119°-121° C. Analysis: Calculated for C10H26N4OS3 : C, 49.71; H, 6.78; N, 14.49. Found: C, 48.98; H, 6.76; N, 14.34.

1. temperaturewas heated
2. temperatureat reflux in a dry nitrogen atmosphere overnight
3. temperatureOn cooling
4. customThe solid was collected
5. washwashed with cold ethanol
6. customrecrystallized from ethanol