Lawesson's reagent → HCID 19095163, compound

HRID 486395Notes

Reaction equation

HRID 486395 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]([N:5]=[C:6]1[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[CH:9]=[C:8]([CH3:21])[S:7]1)=O.COC1C=CC(P2(=S)SP(=S)(C3C=CC(OC)=CC=3)[S:33]2)=CC=1>C1COCC1>[F:1][C:2]([F:23])([F:22])[C:3]([N:5]=[C:6]1[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[CH:9]=[C:8]([CH3:21])[S:7]1)=[S:33]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 15239669HCID 15239669, compound

Product 1

HCID 19095163HCID 19095163, compoundYield 47.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2-(trifluoroacetyl)imino-3-[3-(trifluoromethyl)phenyl]-5-methylthiazoline (1 g) and 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide (2 g) in THF (10 ml) was refluxed for 2 days. After cooling and removal of the solvent under reduced pressure, the concentrated residue was added pottasium hydrogencarbonate, The obtained crystallines were recrystallized to give 0.5 g of 2-[trifluoromethyl(thiocarbonyl)imino]-3-[3-(trifluoromethyl)phenyl]-5-methylthiazoline (Compound No. 2)

Workup

  1. temperatureAfter cooling
  2. customremoval of the solvent under reduced pressure
  3. additionthe concentrated residue was added pottasium hydrogencarbonate
  4. customThe obtained crystallines were recrystallized

Sources & evidence

ORD record
ord-f96f2994abfe4a018b9e349ca2fc6f31
Source dataset
uspto-grants-1994_03
Patent number
US05292715

Reaction notes

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