56-03-1 → HCID 14953278, compound

HRID 486401Notes

Reaction equation

HRID 486401 reaction equation
[C:1]([NH2:7])([NH2:6])=[N:2][C:3]([NH2:5])=[NH:4].CN=[C:10]=[S:11].[CH3:12]N(C)C=O>>[NH2:6][C:1]1[N:2]=[C:3]([NH2:5])[N:4]([CH3:12])[C:10](=[S:11])[N:7]=1

Participants

4

Reactant 3

HCID 593956-03-1HCID 6228DimethylformamideHCID 11167Methyl isothiocyanate

Product 1

HCID 14953278HCID 14953278, compound

Conditions

Temperature
100 °C

Procedure

To 12 of dry dimethylformamide were dissolved 1.52 g of diguanide and 1.1 g of methylisothiocyanate, and the solution was heated at 100° C. for 30 minutes to produce white precipitates. After filtering off the precipitates rapidly, the filtrate was added to 500 ml of ice water to produce precipitates, which was subsequently filtered and recrystalized with 25 ml of 50% ethanol to obtain 2 g of the title compound having the characteristics of:

Workup

  1. customto produce white precipitates
  2. filtrationAfter filtering off the
  3. customprecipitates rapidly
  4. additionthe filtrate was added to 500 ml of ice water
  5. customto produce
  6. customprecipitates
  7. filtrationwhich was subsequently filtered
  8. customrecrystalized with 25 ml of 50% ethanol

Sources & evidence

ORD record
ord-492425d13ff143fea8bc0577535f0143
Source dataset
uspto-grants-1994_03
Patent number
US05292733

Reaction notes

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