反应详情

温度

180 °C

To a stirred solution of 0.7 parts of sodium in 20 parts of benzenemethanol were added 5.8 parts of 3-chloro-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine. The whole was stirred and heated in an oil bath at 180° C. After standing overnight, water was added and the product was extracted with trichloromethane. The extract was dried, filtered and evaporated. 2,2'-Oxybispropane was added to the residue. The product was filtered off and crystallized from a mixture of 2-propanol and methanol. The product was filtered off and dried, yielding 3.4 parts (47%) of 3-[4-(3-methylphenyl)-1-piperazinyl]-6-(phenylmethoxy)pyridazine: mp. 159.4° C. (compound 267).

1. extractionthe product was extracted with trichloromethane
2. customThe extract was dried
3. filtrationfiltered
4. customevaporated
5. addition2,2'-Oxybispropane was added to the residue
6. filtrationThe product was filtered off
7. customcrystallized from a mixture of 2-propanol and methanol
8. filtrationThe product was filtered off
9. customdried