HCID 53635372, compound → HCID 53700867, compound

HRID 486481Notes

Reaction equation

HRID 486481 reaction equation
[C:1]1([C:7](=[CH:19][C:20]2[CH:25]=[N:24][CH:23]=[CH:22][N:21]=2)[C:8]([O:10][C@@H:11]2[CH:16]3[CH2:17][CH2:18][N:13]([CH2:14][CH2:15]3)[CH2:12]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.[Pd]>[C:1]1([CH:7]([CH2:19][C:20]2[CH:25]=[N:24][CH:23]=[CH:22][N:21]=2)[C:8]([O:10][C@@H:11]2[CH:16]3[CH2:15][CH2:14][N:13]([CH2:18][CH2:17]3)[CH2:12]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 53635372HCID 53635372, compound

Product 1

HCID 53700867HCID 53700867, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of (R)-3-quinuclidinyl 2-phenyl-3-(pyrazin-2-yl)acrylate (see Preparation 4) (350 mg) in ethanol (20 ml) containing 10% palladium-on-carbon (30 mg) was stirred for 24 hours under an atmosphere of hydrogen [344.7 kPa (50 psi)] at room temperature. The mixture was filtered and evaporated to leave the title compound as an oil (320 mg, 91%).

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-88f2464243824c9da78e70a3676cb7ec
Source dataset
uspto-grants-1994_03
Patent number
US05292749

Reaction notes

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