反应详情

温度

160 °C

Methyl (RS)-4-cyano-2-phenylbutanoate (see Preparation 21) (1.8 g) and tri-n-butyltin azide (3.23 g were mixed and heated at 160° C. for 3 hours, dissolved in methanol (100 ml), treated by the addition of hydrogen chloride gas for 10 minutes and left for 18 hours. Evaporation gave a residue which was triturated three times with diisopropyl ether then partitioned between 10% aqueous sodium carbonate and ethyl acetate. The aqueous later was acidifed with 2 M hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over magnesium sulphate and evaporated to give the title compound (1.34 g, 61%) as a brown oil.

1. customEvaporation
2. customgave a residue which
3. customwas triturated three times with diisopropyl ether
4. customthen partitioned between 10% aqueous sodium carbonate and ethyl acetate
5. extractionextracted with ethyl acetate
6. dry with materialThe organic layer was dried over magnesium sulphate
7. customevaporated