Sodium Hydroxide → 4-Chloro-5,6,10,11-tetrahydro-8-methylbenz[g]pyrazino[1,2-a]indole fumarate

HRID 486538Notes

Reaction equation

[Cl:1][C:2]1[C:7]2[CH2:8][CH2:9][C:10]3[CH:11]=[CH:12][N:13]([CH2:15][CH2:16][NH:17][C:18](=O)[CH3:19])[C:14]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O.[OH-].[Na+].[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32]>C(O)C>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[Cl:1][C:2]1[C:7]2[CH2:8][CH2:9][C:10]3[CH:11]=[C:12]4[C:18]([CH3:19])=[N:17][CH2:16][CH2:15][N:13]4[C:14]=3[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 100 °C

Procedure

N-[2-(6-Chloro-4,5-dihydro-1H-benz[g]indol-1-yl)ethyl]acetamide (6.0 g) was treated with 30 ml of phosphorus oxychloride and the mixture was stirred at 100° C. for 30 minutes. The cooled mixture was added to 2500 g of ice-water and treated with 100 ml of 2N sodium hydroxide solution and 200 ml of 28% sodium hydroxide solution. The mixture was extracted once with 300 ml of methylene chloride and twice with 100 ml of methylene chloride each time, the organic phases were combined, dried with MgSO4 and freed from solvent. 5.7 g of residue were dissolved in a 20-fold amount of hot ethanol and treated while hot with 1.1 equivalents of a saturated solution of fumaric acid in ethanol. There were obtained 6.6 g (82%) of 4-chloro-5,6,10,11-tetrahydro-8-methylbenz[g]pyrazino[1,2-a]indole fumarate (1:1); m.pt.: 191°-192° C. (dec.).

Workup

extractionThe mixture was extracted once with 300 ml of methylene chloride and twice with 100 ml of methylene chloride each time
dry with materialdried with MgSO4
dissolution5.7 g of residue were dissolved in a 20-fold amount of hot ethanol

Sources & evidence

ORD record: ord-986ca584e5c946aaa05920797662f876
Source dataset: uspto-grants-1994_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05292732

Reaction notes

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