Sodium Hydroxide → HCID 86747631, compound

HRID 486598Notes

Reaction equation

HRID 486598 reaction equation
C([O:4][C@H:5]1[CH2:18][C@@H:17]([O:19]C(=O)C)[C@H:16](/[CH:23]=[CH:24]/[CH:25]=[CH:26]/[CH2:27][CH2:28][CH2:29][CH3:30])[C@H:6]1[CH2:7]/[CH:8]=[CH:9]\[CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])(=O)C.[OH-].[Na+]>CO>[OH:4][C@H:5]1[CH2:18][C@@H:17]([OH:19])[C@H:16](/[CH:23]=[CH:24]/[CH:25]=[CH:26]/[CH2:27][CH2:28][CH2:29][CH3:30])[C@H:6]1[CH2:7]/[CH:8]=[CH:9]\[CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86747632HCID 86747632, compound

Product 1

HCID 86747631HCID 86747631, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound 121 obtained above (3.90 g, 9.27 mmole) was dissolved in methanol (40 ml), and 10% aqueous sodium hydroxide was added to the solution, and the mixture was stirred at room temperature for one hour. Then, the mixture was treated following the procedure similar to that of Example 44 to yield a residue (2.84 g). The residue was purified with Lobar column (ethyl acetate:n-hexane:acetic acid=50:50:1), to yield the title compound 122 (2.67 g, 84%).

Workup

  1. additionThen, the mixture was treated

Sources & evidence

ORD record
ord-b6cfd787104049cf9a788622946f9ac4
Source dataset
uspto-grants-1994_03
Patent number
US05292754

Reaction notes

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