Hydrochloric Acid → HCID 178441834, compound

HRID 486622Notes

Reaction equation

HRID 486622 reaction equation
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]#[N:17])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].C([Sn](Cl)(CCCC)CCCC)CCC.[N-:32]=[N+:33]=[N-:34].[Na+].Cl>C1(C)C=CC=CC=1.CCCCCC>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]1[NH:34][N:33]=[N:32][N:17]=1)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 15096Tributyltin ChlorideHCID 33557Sodium AzideHCID 178441853HCID 178441853, compound

Product 1

HCID 178441834HCID 178441834, compoundYield 114.7%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 8058HexaneSolvent

Procedure

A mixture of 1.1 g of 2-Butyl-6-cyano-4(1H)-quinazolinone 3.2 g of tri-n-butyltin chloride and 640 mg of sodium azide in 30 ml of toluene is heated at reflux for 48 hours. The reaction mixture is cooled to room temperature and dry HCl gas passed through the reaction mixture for 10 minutes. The reaction mixture is diluted with hexane and filtered. The residue is dried, washed with water and dried to give 1.5 g of the desired product as a solid, m.p. 225° C.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 48 hours
  3. filtrationfiltered
  4. customThe residue is dried
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-65a8f0d2f0b047d4b38527f4fb17842c
Source dataset
uspto-grants-1994_03
Patent number
US05292742

Reaction notes

Loading…