4-tert-Butylbenzenesulfonamide → N-[5-(1,3-benzodioxol-5-yloxy)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-p-tert-butylbenzenesulfonamide

HRID 486641Notes

Reaction equation

HRID 486641 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][C:11]3[C:12](Cl)=[N:13][CH:14]=[N:15][C:16]=3Cl)=[CH:9][C:4]=2[O:3][CH2:2]1.[C:19]([C:23]1[CH:28]=[CH:27][C:26]([S:29]([NH2:32])(=[O:31])=[O:30])=[CH:25][CH:24]=1)([CH3:22])([CH3:21])[CH3:20]>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([O:10][C:11]3[C:12]([NH:32][S:29]([C:26]4[CH:27]=[CH:28][C:23]([C:19]([CH3:22])([CH3:20])[CH3:21])=[CH:24][CH:25]=4)(=[O:30])=[O:31])=[N:13][CH:14]=[N:15][C:16]=3[O:1][CH2:5][CH2:4][OH:3])=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 2228724-tert-ButylbenzenesulfonamideHCID 19095638HCID 19095638, compound

Product 1

HCID 19095801N-[5-(1,3-benzodioxol-5-yloxy)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-p-tert-butylbenzenesulfonamide

Procedure

By reacting 5-(1,3-benzodioxol-5-yloxy)-4,6-dichloropyrimidine with p-tert-butylphenylsulfonamide and thereafter with ethylene glycol Na, there was obtained N-[5-(1,3-benzodioxol-5-yloxy)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-p-tert-butylbenzenesulfonamide as a solid.

Sources & evidence

ORD record
ord-7d40bf7d9ae0433aa62c3e1b7bb1b996
Source dataset
uspto-grants-1994_03
Patent number
US05292740

Reaction notes

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