Hydroxyamine hydrochloride → HCID 76538950, compound

HRID 486684Notes

Reaction equation

HRID 486684 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](=O)[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16].Cl.[NH2:20][OH:21].O.O.O.C([O-])(=O)C.[Na+]>C(O)C.O>[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](=[N:20][OH:21])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16]

Participants

6

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 11777428HCID 11777428, compoundHCID 23665404Sodium Acetate Trihydrate

Product 1

HCID 76538950HCID 76538950, compoundYield 76.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

A mixture of 22.0 g of 1-(3-methyl-2-thienyl)-2-(2-nitrophenyl)ethanone in 210 ml of 95% ethanol, 11.7 g of hydroxylamine hydrochloride in 28 ml water, and 25.04 g of sodium acetate trihydrate in 28 ml water was refluxed overnight. The mixture was allowed to cool. The precipitate was collected and crystallized from 95% ethanol to give 17.85 g of product, mp 105°-100° C.

Workup

  1. temperatureto cool
  2. customThe precipitate was collected
  3. customcrystallized from 95% ethanol

Sources & evidence

ORD record
ord-1e2f879c2cde4fa1b4bf078d983d9fcc
Source dataset
uspto-grants-1994_03
Patent number
US05292760

Reaction notes

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