Acetic Anhydride → HCID 54572216, compound

HRID 486731Notes

Reaction equation

HRID 486731 reaction equation
[C:1]([C@@H:4]1[CH2:8][S:7][C@@H:6]([C:9]([SH:12])([CH3:11])[CH3:10])[CH2:5]1)([OH:3])=[O:2].[C:13](OC(=O)C)(=[O:15])[CH3:14]>N1C=CC=CC=1>[C:13]([S:12][C:9]([C@H:6]1[CH2:5][C@H:4]([C:1]([OH:3])=[O:2])[CH2:8][S:7]1)([CH3:10])[CH3:11])(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 54060056HCID 54060056, compound

Product 1

HCID 54572216HCID 54572216, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

trans-4-carboxy-2-(1-mercapto-1-methylethyl)tetrahydrothiophene (compound No. 8-1, 50 mg) was dissolved in a mixture of acetic anhydride (1 ml) and pyridine (1 ml) and the mixture was stirred over night at room temperature. The reaction mixture was concentrated in vacuo and the oily residue was purified by a silica gel column chromatography to give 43 mg (72%) of the titled compound (compound No. 13-1).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe oily residue was purified by a silica gel column chromatography

Sources & evidence

ORD record
ord-39083ce92f38417980f3f716cd655d02
Source dataset
uspto-grants-1994_03
Patent number
US05292767

Reaction notes

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