Diazomethane → HCID 54458810, compound

HRID 486738Notes

Reaction equation

HRID 486738 reaction equation
[N+](=[CH2:3])=[N-].[CH2:4]([O:6][C:7]([C@@H:9]1[CH2:13][S:12][C@@H:11]([CH2:14][SH:15])[CH2:10]1)=[O:8])[CH3:5]>C(OCC)C>[CH2:4]([O:6][C:7]([C@@H:9]1[CH2:13][S:12][C@@H:11]([CH2:14][S:15][CH3:3])[CH2:10]1)=[O:8])[CH3:5]

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 53870179HCID 53870179, compound

Product 1

HCID 54458810HCID 54458810, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Diethylether solution of diazomethane (10 molar equivalents) was added to trans-4-ethoxycarbonyl-2-mercaptomethyltetrahydrothiophene (compound No. 15-1, 549 mg) and the mixture was stirred for 4 hours at room temperature. The mixture was concentrated in vacuo and the oil residue was purified by a silica gel column chromatography to give 407 mg (69%) of the titled compound (compound No. 18-1).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe oil residue was purified by a silica gel column chromatography

Sources & evidence

ORD record
ord-e8ce920e19bd449c9509d545d759acd5
Source dataset
uspto-grants-1994_03
Patent number
US05292767

Reaction notes

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