Hydrochloric Acid → HCID 86747638, compound

Participants

Reaction Steps

(2R,4R)-N-(5-tert-butoxycarbonylaminopentyl)-2-mercaptomethyl-4-tetrahydrothiophenecarboxamide (compound No. 20-4, 35 mg) was added to 2.3N ethyl acetate solution of hydrogen chloride (3 ml) and the mixture was stirred for 2 hours at room temperature. The mixture was concentrated in vacuo and the oily residue was purified by a silica gel column chromatography to give 11.3 mg (39%) of the titled compound (compound No. 21-1).

Provenance & Evidence