Hydrochloric Acid → HCID 86747638, compound

HRID 486740Notes

Reaction equation

HRID 486740 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]([C@@H:17]1[CH2:21][S:20][C@@H:19]([CH2:22][SH:23])[CH2:18]1)=[O:16])=O)(C)(C)C.[ClH:24]>C(OCC)(=O)C>[ClH:24].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]([C@@H:17]1[CH2:21][S:20][C@@H:19]([CH2:22][SH:23])[CH2:18]1)=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54171219HCID 54171219, compound

Product 1

HCID 86747638HCID 86747638, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

(2R,4R)-N-(5-tert-butoxycarbonylaminopentyl)-2-mercaptomethyl-4-tetrahydrothiophenecarboxamide (compound No. 20-4, 35 mg) was added to 2.3N ethyl acetate solution of hydrogen chloride (3 ml) and the mixture was stirred for 2 hours at room temperature. The mixture was concentrated in vacuo and the oily residue was purified by a silica gel column chromatography to give 11.3 mg (39%) of the titled compound (compound No. 21-1).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe oily residue was purified by a silica gel column chromatography

Sources & evidence

ORD record
ord-c1c01904df5143ed9a99bb67ec961cf5
Source dataset
uspto-grants-1994_03
Patent number
US05292767

Reaction notes

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