反应详情

To a solution of N-(2-mercapto-2-methylpropionyl)-L-cysteine (1.0 g) in ether(3 ml), diazomethane dissolved in ether(12 ml) was added dropwise under ice-cooling. After the addition, acetic acid was added to the reaction mixture. The reaction mixture was washed with saturated sodium hydrogen carbonate solution and saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo. The oily residue was purified by a silica gel column chromatography to give 1.0 g(94%) of the titled compound.

1. additionwas added dropwise under ice-
2. temperaturecooling
3. additionwas added to the reaction mixture
4. washThe reaction mixture was washed with saturated sodium hydrogen carbonate solution and saturated sodium chloride solution
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated in vacuo
7. customThe oily residue was purified by a silica gel column chromatography