反应详情

温度

-20 °C

About 600 ml of 1.5M methyllithium (solution in ether) was added to 500 ml of tetrahydrofuran. A suspension of 93.45 g of 5-acetyl-1,3-benzodioxole in 900 ml of tetrahydrofuran was added thereto under cooling at -20° C. The mixture was stirred under these conditions for 1 h. Water was added to the reaction mixture. The product was extracted with ethyl acetate, washed with a saturated aqueous common salt solution and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to obtain 97 g of the intended compound in the form of an oil.

1. additionwas added
2. extractionThe product was extracted with ethyl acetate
3. washwashed with a saturated aqueous common salt solution
4. dry with materialdried over anhydrous magnesium sulfate
5. filtrationAfter filtration
6. concentrationthe filtrate was concentrated